Michael Lee

Vice Chanc Research

Type 1 diabetes immunotherapy using polyclonal regulatory T cells.

Science translational medicine

Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950)

McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, Hoffmüller U, Baron U, Olek S, Bluestone JA, Brusko TM

Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.

PloS one

Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, Nishimura MI, Han S, Chang LJ, Atkinson MA, Ribas A, Bluestone JA

Successful clinical islet isolation using a GMP-manufactured collagenase and neutral protease.


Szot GL, Lee MR, Tavakol MM, Lang J, Dekovic F, Kerlan RK, Stock PG, Posselt AM

T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.

Journal of immunology (Baltimore, Md. : 1950)

Esensten JH, Lee MR, Glimcher LH, Bluestone JA

Expansion of human regulatory T-cells from patients with type 1 diabetes.


Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.

Proceedings of the National Academy of Sciences of the United States of America

Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.

The Journal of experimental medicine

Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA