Leonardo Ramos Ferreira, PhD

Postdoctoral Scholar
(co-advised by Qizhi Tang)
Surgery
Email: 
Leonardo.Ferreira@ucsf.edu

Cell-based gene therapies offer unprecedented promise for medicine. One day, it may be possible to cure degenerative diseases consisting of the loss of specialized cellular functions. However, several hurdles must be surpassed to establish cell transplantation therapies. A major one is rejection by the recipient's immune system. This challenge is particularly prominent for autoimmune disorders, such as type 1 diabetes and multiple sclerosis, where the immune system mediates the destruction of self-tissues. Currently, I am a postdoctoral scholar in the Tang and Bluestone laboratories at the Department of Surgery and Diabetes Center at UCSF. I envision that we will be able to use our capacity to engineer the human genome to manipulate our immune system with high precision and efficiency, enabling us to treat devastating illnesses now labeled as incurable. I am highly committed to make this vision become a reality.

Publications: 

NLRP2 is a suppressor of NF-ƙB signaling and HLA-C expression in human trophoblasts.

Biology of reproduction

Tilburgs T, Meissner TB, Ferreira LM, Mulder A, Musunuru K, Ye J, Strominger JL

HLA-G: At the Interface of Maternal-Fetal Tolerance.

Trends in immunology

Ferreira LM, Meissner TB, Tilburgs T, Strominger JL

Generating antigen-specific regulatory T cells in the fast lane.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Ferreira LM, Tang Q

A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.

Proceedings of the National Academy of Sciences of the United States of America

Ferreira LM, Meissner TB, Mikkelsen TS, Mallard W, O'Donnell CW, Tilburgs T, Gomes HA, Camahort R, Sherwood RI, Gifford DK, Rinn JL, Cowan CA, Strominger JL

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9.

Cell stem cell

Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, Rossi DJ, Cowan CA

Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

Abreu PL, Ferreira LM, Alpoim MC, Urbano AM

Genome editing for human gene therapy.

Methods in enzymology

Meissner TB, Mandal PK, Ferreira LM, Rossi DJ, Cowan CA

Gammadelta T cells: innately adaptive immune cells?

International reviews of immunology

Ferreira LM

Neural regeneration: lessons from regenerating and non-regenerating systems.

Molecular neurobiology

Ferreira LM, Floriddia EM, Quadrato G, Di Giovanni S

Metabolic reprogramming of the tumor.

Oncogene

Ferreira LM, Hebrant A, Dumont JE

DNA Repair and Human Health (ed. Sonya Vengrova)

DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy

Urbano AM, Ferreira LM, Cerveira JF, Rodrigues CF, Alpoim MC

Cancer metabolism: the Warburg effect today.

Experimental and molecular pathology

Ferreira LM