Jeffrey Bluestone, PhD

A.W. and Mary Margaret Clausen Distinguished Professor 

Director, Hormone Research Institute
M_Diabetes Center

Jeffrey Bluestone, PhD, is the A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology and is the Director of the Hormone Research Institute in the Diabetes Center. His research over the past 25 years has focused on understanding the basic processes that control T cell activation and immune tolerance in autoimmunity and organ transplantation. He and members of his lab have developed soluble receptor antagonists; monoclonal antibodies and animals deficient in individual members of TCR and co-stimulatory pathways to define their individual roles in transplant rejection and autoimmunity including a special emphasis on a specialized subset of T cells termed “regulatory T cells” (Treg). Tregs control fundamental aspect of immune homeostasis. During the last several years, his research has adapted the animal studies using biologics and cell based therapies to develop therapeutics that can be used in humans with autoimmunity and under conditions of allotransplant rejection. Moreover, a strong role for antigen-specific Tregs have been found in these model systems and further evidence in humanized mice and transplant patients that alloantigen-specific Tregs are more effective. Thus, the major goal of this work is to identify the antigen-specificity of thymic- and peripherally-derived Tregs with the expectation that these TCRs can be adapted for immunotherapy. Finally, his lab initiated several projects to determine mechanisms that control Treg stability. The goal is to develop approaches using pharmacogenomics to either stabilize or destabilize Tregs in autoimmunity and cancer.

In March 2010 Dr. Bluestone was appointed executive vice chancellor and provost at the University of California San Francisco (UCSF) serving as chief academic officer guiding the research and academic enterprise advancing the campus priorities in close collaboration with the chancellor and the campus leadership teams, and to oversee the campus ethics and compliance enterprise. Previously he served in a number of posts including Director of theUCSF Diabetes Center, as Director of the Immune Tolerance Network.

In June 2008 Dr. Bluestone served as interim vice chancellor of research; directing the advancement of cross-campus research initiatives, such as enhancing core research facilities. In this capacity, he played a leading role in coordinating and integrating current research cores. He worked also to strengthen external research partnerships, particularly with industry, and focused on facilitating the translation of UCSF discoveries into public benefit.

In 2009, Dr. Bluestone led the UCSF committee to strategize and secure funds available through the American Recovery and Reinvestment Act, making the campus one of the top institutional recipients in the nation of science-based stimulus funds.

Dr. Bluestone joined the UCSF faculty in 2000. He is an international leader in the field of immunotherapy, with a stellar record of scholarly achievement and a decade of significant contributions to the research enterprise at UCSF, including the creation and directorship of an integrated UCSF Diabetes Center to focus on translating basic research in both type 1 and type 2 diabetes into improved therapies for patients. He also founded and directed the Immune Tolerance Network, a consortium of more than 1,000 of the world’s leading scientific researchers and clinical specialists from nearly 50 institutions, with the mission of testing new therapies to promote immune tolerance in transplantation, autoimmune diseases, asthma and allergic diseases.

As a research scientist, Dr. Bluestone has helped clarify the body’s immune response on a molecular level. His systematic investigation has catalyzed recent progress in stem cell research, islet cell transplantation and immune tolerance therapies – experimentation that has formidably translated into drugs to treat human disease.

Through his 30-year scientific career, he has authored more than 300 peer-reviewed publications that include prominent papers in Nature, Nature Immunology, and the Journal of Immunology and Diabetes. He has received numerous accolades for his work, including his 2006 election to the American Academy of Arts and Sciences, the Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award from the Juvenile Diabetes Research Foundation, and the distinguished alumni award from the Cornell Graduate School of Medical Science.

Prior to joining UCSF, Bluestone was at the University of Chicago, where he was a member of the Ben May Institute for Cancer Research, rising over 13 years from an associate professor to the director of the institute. He had previously worked for seven years in various roles at the National Cancer Institute of the National Institutes of Health, ultimately becoming a senior investigator in the Immunology Branch of the National Cancer Institute.

Dr. Bluestone earned both his BS in biology and his MS in microbiology from Rutgers State University, and his PhD in immunology from the Cornell Graduate School of Medical Science (Sloan-Kettering Division).

Publications: 

Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes.

Cell metabolism

Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR

Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials.

Annual review of pathology

Esensten JH, Bluestone JA, Lim WA

CD28 Costimulation: From Mechanism to Therapy.

Immunity

Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA

Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.

Journal of immunology (Baltimore, Md. : 1950)

Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF

Regulatory T cell therapy for type 1 diabetes: May the force be with you.

Journal of autoimmunity

Gitelman SE, Bluestone JA

Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial.

Diabetologia

Gitelman SE, Gottlieb PA, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Keyes-Elstein L, Harris KM, Kanaparthi S, Phippard D, Ding L, Bluestone JA, Ehlers MR

CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.

Journal of immunology (Baltimore, Md. : 1950)

Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF

Inducing and Administering Tregs to Treat Human Disease.

Frontiers in immunology

Perdigoto AL, Chatenoud L, Bluestone JA, Herold KC

Type 1 diabetes immunotherapy using polyclonal regulatory T cells.

Science translational medicine

Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q

Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction.

Molecular genetics and metabolism

Kishnani PS, Dickson PI, Muldowney L, Lee JJ, Rosenberg A, Abichandani R, Bluestone JA, Burton BK, Dewey M, Freitas A, Gavin D, Griebel D, Hogan M, Holland S, Tanpaiboon P, Turka LA, Utz JJ, Wang YM, Whitley CB, Kazi ZB, Pariser AR

Shifting the Evolving CAR T Cell Platform into Higher Gear.

Cancer cell

Holohan DR, Lee JC, Bluestone JA

Targeting Treg signaling for the treatment of autoimmune diseases.

Current opinion in immunology

Spence A, Klementowicz JE, Bluestone JA, Tang Q

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

Proceedings of the National Academy of Sciences of the United States of America

Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A

Interleukin-33 and Interferon-? Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.

Immunity

Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

Journal of immunology (Baltimore, Md. : 1950)

Fuhrman CA, Yeh WI, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, von Schack D, Atkinson MA, Bluestone JA, Brusko TM

IL-2: Change Structure … Change Function.

Immunity

Bluestone JA, Crellin N, Trotta E

T cells in the control of organ-specific autoimmunity.

The Journal of clinical investigation

Bluestone JA, Bour-Jordan H, Cheng M, Anderson M

The therapeutic potential of regulatory T cells for the treatment of autoimmune disease.

Expert opinion on therapeutic targets

Bluestone JA, Trotta E, Xu D

Immunotherapy: making the case for precision medicine.

Science translational medicine

Bluestone JA, Tang Q

The immune system in Duchenne muscular dystrophy: Friend or foe.

Rare diseases (Austin, Tex.)

Villalta SA, Rosenberg AS, Bluestone JA

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation.

Immunity

DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.

Nature immunology

Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA

Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling.

Molecular cell

Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R

Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm.

Cell stem cell

Szot GL, Yadav M, Lang J, Kroon E, Kerr J, Kadoya K, Brandon EP, Baetge EE, Bour-Jordan H, Bluestone JA

Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.

Blood

Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy.

Science translational medicine

Villalta SA, Rosenthal W, Martinez L, Kaur A, Sparwasser T, Tidball JG, Margeta M, Spencer MJ, Bluestone JA

Aberrant innate immune activation following tissue injury impairs pancreatic regeneration.

PloS one

Folias AE, Penaranda C, Su AL, Bluestone JA, Hebrok M

Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function.

European journal of immunology

Stumpf M, Zhou X, Chikuma S, Bluestone JA

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.

Nature medicine

Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone JA, Takayanagi H

Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response.

Immunity

Bailey-Bucktrout SL, Martinez-Llordella M, Zhou X, Anthony B, Rosenthal W, Luche H, Fehling HJ, Bluestone JA

Regulatory T-cell therapy in transplantation: moving to the clinic.

Cold Spring Harbor perspectives in medicine

Tang Q, Bluestone JA

Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Putnam AL, Safinia N, Medvec A, Laszkowska M, Wray M, Mintz MA, Trotta E, Szot GL, Liu W, Lares A, Lee K, Laing A, Lechler RI, Riley JL, Bluestone JA, Lombardi G, Tang Q

Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial.

The lancet. Diabetes & endocrinology

Gitelman SE, Gottlieb PA, Rigby MR, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, Ding L, Bluestone JA, Ehlers MR

Peripherally induced tregs - role in immune homeostasis and autoimmunity.

Frontiers in immunology

Yadav M, Stephan S, Bluestone JA

CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response.

The Journal of experimental medicine

Martínez-Llordella M, Esensten JH, Bailey-Bucktrout SL, Lipsky RH, Marini A, Chen J, Mughal M, Mattson MP, Taub DD, Bluestone JA

Production of a-galactosylceramide by a prominent member of the human gut microbiota.

PLoS biology

Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach MA

microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

de Kouchkovsky D, Esensten JH, Rosenthal WL, Morar MM, Bluestone JA, Jeker LT

Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.

Journal of autoimmunity

Bour-Jordan H, Thompson HL, Giampaolo JR, Davini D, Rosenthal W, Bluestone JA

Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function.

Diabetes

Villalta SA, Lang J, Kubeck S, Kabre B, Szot GL, Calderon B, Wasserfall C, Atkinson MA, Brekken RA, Pullen N, Arch RH, Bluestone JA

Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders.

Diabetes

Herold KC, Gitelman SE, Ehlers MR, Gottlieb PA, Greenbaum CJ, Hagopian W, Boyle KD, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, McNamara J, Bluestone JA

The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.

Nature immunology

Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT

MicroRNA regulation of T-cell differentiation and function.

Immunological reviews

Jeker LT, Bluestone JA

Cell-based therapeutics: the next pillar of medicine.

Science translational medicine

Fischbach MA, Bluestone JA, Lim WA

Type 1 diabetes: translating mechanistic observations into effective clinical outcomes.

Nature reviews. Immunology

Herold KC, Vignali DA, Cooke A, Bluestone JA

Regulatory T cells: recommendations to simplify the nomenclature.

Nature immunology

Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF

Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28.

Journal of immunology (Baltimore, Md. : 1950)

Huang C, Martin S, Pfleger C, Du J, Buckner JH, Bluestone JA, Riley JL, Ziegler SF

Immune therapy and ß-cell death in type 1 diabetes.

Diabetes

Lebastchi J, Deng S, Lebastchi AH, Beshar I, Gitelman S, Willi S, Gottlieb P, Akirav EM, Bluestone JA, Herold KC

The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950)

Stumpf M, Zhou X, Bluestone JA

Current and future immunomodulation strategies to restore tolerance in autoimmune diseases.

Cold Spring Harbor perspectives in biology

Bluestone JA, Bour-Jordan H

Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial.

Diabetologia

Herold KC, Gitelman SE, Willi SM, Gottlieb PA, Waldron-Lynch F, Devine L, Sherr J, Rosenthal SM, Adi S, Jalaludin MY, Michels AW, Dziura J, Bluestone JA

Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients.

Transplant international : official journal of the European Society for Organ Transplantation

Tang Q, Leung J, Melli K, Lay K, Chuu EL, Liu W, Bluestone JA, Kang SM, Peddi VR, Vincenti F

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo.

The Journal of experimental medicine

Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, Anthony BA, Sverdrup FM, Head R, Kuster DJ, Ruminski P, Weiss D, Von Schack D, Bluestone JA

Single step isolation and activation of primary CD3+ T lymphocytes using alcohol-dispersed electrospun magnetic nanofibers.

Nano letters

Kim K, An HJ, Jun SH, Kim TJ, Lim SA, Park G, Na HB, Park YI, Hyeon T, Yee C, Bluestone JA, Kim J, Lee KM

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.

Proceedings of the National Academy of Sciences of the United States of America

Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas AK, Dooms H

Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs ß-cell function.

Diabetes

Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, Bluestone JA, Buckner JH, Greenbaum CJ

MicroRNA 10a marks regulatory T cells.

PloS one

Jeker LT, Zhou X, Gershberg K, de Kouchkovsky D, Morar MM, Stadthagen G, Lund AH, Bluestone JA

NK cells are not required for spontaneous autoimmune diabetes in NOD mice.

PloS one

Beilke JN, Meagher CT, Hosiawa K, Champsaur M, Bluestone JA, Lanier LL

A resource for the conditional ablation of microRNAs in the mouse.

Cell reports

Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT

Breakdown in peripheral tolerance in type 1 diabetes in mice and humans.

Cold Spring Harbor perspectives in medicine

Jeker LT, Bour-Jordan H, Bluestone JA

CD4(+)Foxp3(+) regulatory T cell therapy in transplantation.

Journal of molecular cell biology

Tang Q, Bluestone JA, Kang SM

The yin and yang of interleukin-2-mediated immunotherapy.

The New England journal of medicine

Bluestone JA

A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse.

Journal of immunology (Baltimore, Md. : 1950)

Tada A, Shimada A, Yamada T, Oikawa Y, Yamada Y, Okubo Y, Irie J, Bluestone JA, Itoh H

Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413.

Journal of immunology (Baltimore, Md. : 1950)

Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.

Nature immunology

Beyer M, Thabet Y, Müller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schönfeld EA, Böttcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL, Schultze JL

Type 1 diabetes immunotherapy: is the glass half empty or half full?

Science translational medicine

Herold KC, Bluestone JA

Control of TH17 cells occurs in the small intestine.

Nature

Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA

Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Penaranda C, Tang Q, Bluestone JA

Regulatory T cells: stability revisited.

Trends in immunology

Bailey-Bucktrout SL, Bluestone JA

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)

Rainbow DB, Moule C, Fraser HI, Clark J, Howlett SK, Burren O, Christensen M, Moody V, Steward CA, Mohammed JP, Fusakio ME, Masteller EL, Finger EB, Houchins JP, Naf D, Koentgen F, Ridgway WM, Todd JA, Bluestone JA, Peterson LB, Mattner J, Wicker LS

Mechanisms of tolerance.

Immunological reviews

Bluestone JA

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/?B7 family.

Immunological reviews

Bour-Jordan H, Esensten JH, Martinez-Llordella M, Penaranda C, Stumpf M, Bluestone JA

How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited.

Diabetes

Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ

Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.

The Journal of surgical research

Brennan TV, Tang Q, Liu FC, Hoang V, Bi M, Bluestone JA, Kang SM

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950)

McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, Hoffmüller U, Baron U, Olek S, Bluestone JA, Brusko TM

Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)

Nikoopour E, Sandrock C, Huszarik K, Krougly O, Lee-Chan E, Masteller EL, Bluestone JA, Singh B

Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.

Transplantation

Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG

Expression of avß8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.

The Journal of clinical investigation

Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D

The Immune Tolerance Network at 10 years: tolerance research at the bedside.

Nature reviews. Immunology

Bluestone JA, Auchincloss H, Nepom GT, Rotrosen D, St Clair EW, Turka LA

Clusterin synergizes with IL-2 for the expansion and IFN-? production of natural killer cells.

Journal of leukocyte biology

Sonn CH, Yu YB, Hong YJ, Shim YJ, Bluestone JA, Min BH, Lee KM

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells.

The Journal of experimental medicine

Grinberg-Bleyer Y, Baeyens A, You S, Elhage R, Fourcade G, Gregoire S, Cagnard N, Carpentier W, Tang Q, Bluestone J, Chatenoud L, Klatzmann D, Salomon BL, Piaggio E

Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG

FK506 causes cellular and functional defects in human natural killer cells.

Journal of leukocyte biology

Kim TJ, Kim N, Kang HJ, Kim EO, Kim ST, Ahn HS, Bluestone JA, Lee KM

Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.

PloS one

Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, Nishimura MI, Han S, Chang LJ, Atkinson MA, Ribas A, Bluestone JA

The Type 1 Diabetes PhysioLab Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse.

Clinical and experimental immunology

Shoda L, Kreuwel H, Gadkar K, Zheng Y, Whiting C, Atkinson M, Bluestone J, Mathis D, Young D, Ramanujan S

Small RNA regulators of T cell-mediated autoimmunity.

Journal of clinical immunology

Jeker LT, Bluestone JA

Ten years of the Immune Tolerance Network: an integrated clinical research organization.

Science translational medicine

Bluestone JA, Krensky AM, Turka LA, Rotrosen D, Matthews JB

Regulatory T cells directed to the site of the action.

Proceedings of the National Academy of Sciences of the United States of America

Brusko TM, Bluestone JA

Autoimmunity.

Current opinion in immunology

Bluestone JA, Kuchroo V

The functional plasticity of T cell subsets.

Nature reviews. Immunology

Bluestone JA, Mackay CR, O'Shea JJ, Stockinger B

Regulatory T cells as therapeutic targets in rheumatoid arthritis.

Nature reviews. Rheumatology

Esensten JH, Wofsy D, Bluestone JA

How suppressor cells led to anergy, costimulation, and beyond.

Journal of immunology (Baltimore, Md. : 1950)

Bour-Jordan H, Bluestone JA

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

Nature immunology

Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.

Nature immunology

Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA

Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice.

Endocrinology

Norquay LD, D'Aquino KE, Opare-Addo LM, Kuznetsova A, Haas M, Bluestone JA, White MF

Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Perruche S, Zhang P, Maruyama T, Bluestone JA, Saas P, Chen W

T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.

Journal of immunology (Baltimore, Md. : 1950)

Esensten JH, Lee MR, Glimcher LH, Bluestone JA

Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.

Gut

Coquerelle C, Oldenhove G, Acolty V, Denoeud J, Vansanten G, Verdebout JM, Mellor A, Bluestone JA, Moser M

Plasticity of CD4(+) FoxP3(+) T cells.

Current opinion in immunology

Zhou X, Bailey-Bucktrout S, Jeker LT, Bluestone JA

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years.

Clinical immunology (Orlando, Fla.)

Herold KC, Gitelman S, Greenbaum C, Puck J, Hagopian W, Gottlieb P, Sayre P, Bianchine P, Wong E, Seyfert-Margolis V, Bourcier K, Bluestone JA

A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.

The Journal of experimental medicine

Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA

The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients.

Clinical immunology (Orlando, Fla.)

Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, Anderson MS

Expansion of human regulatory T-cells from patients with type 1 diabetes.

Diabetes

Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA

Immunoregulatory pathways controlling progression of autoimmunity in NOD mice.

Annals of the New York Academy of Sciences

You S, Alyanakian MA, Segovia B, Damotte D, Bluestone J, Bach JF, Chatenoud L

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.

Proceedings of the National Academy of Sciences of the United States of America

Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA

The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Bluestone JA, Liu W, Yabu JM, Laszik ZG, Putnam A, Belingheri M, Gross DM, Townsend RM, Vincenti F

Innate immunity and intestinal microbiota in the development of Type 1 diabetes.

Nature

Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.

The Journal of experimental medicine

Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA

T regulatory cells in autoimmune diabetes: past challenges, future prospects.

Journal of clinical immunology

Bluestone JA, Tang Q, Sedwick CE

Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.

Diabetes

Fiorina P, Vergani A, Dada S, Jurewicz M, Wong M, Law K, Wu E, Tian Z, Abdi R, Guleria I, Rodig S, Dunussi-Joannopoulos K, Bluestone J, Sayegh MH

Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice.

Journal of immunology (Baltimore, Md. : 1950)

Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, Bluestone JA

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities.

Immunological reviews

Brusko TM, Putnam AL, Bluestone JA

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.

Immunity

Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA

Safer, longer-lasting regulatory T cells with beta-catenin.

Nature medicine

Bluestone JA, Hebrok M

Regulated beta-cell regeneration in the adult mouse pancreas.

Diabetes

Cano DA, Rulifson IC, Heiser PW, Swigart LB, Pelengaris S, German M, Evan GI, Bluestone JA, Hebrok M

B cell depletion: a novel therapy for autoimmune diabetes?

The Journal of clinical investigation

Bour-Jordan H, Bluestone JA

Transplantation of pancreatic islets into the kidney capsule of diabetic mice.

Journal of visualized experiments : JoVE

Szot GL, Koudria P, Bluestone JA

Murine pancreatic islet isolation.

Journal of visualized experiments : JoVE

Szot GL, Koudria P, Bluestone JA

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

Nature

Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.

Endocrinology

Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC

What does the future hold for cell-based tolerogenic therapy?

Nature reviews. Immunology

Bluestone JA, Thomson AW, Shevach EM, Weiner HL

CD3-specific antibodies: a portal to the treatment of autoimmunity.

Nature reviews. Immunology

Chatenoud L, Bluestone JA

Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.

Journal of immunology (Baltimore, Md. : 1950)

Bour-Jordan H, Salomon BL, Thompson HL, Santos R, Abbas AK, Bluestone JA

Mechanisms of PDL1-mediated regulation of autoimmune diabetes.

Clinical immunology (Orlando, Fla.)

Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH

CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Kang SM, Tang Q, Bluestone JA

Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment.

Proceedings of the National Academy of Sciences of the United States of America

You S, Leforban B, Garcia C, Bach JF, Bluestone JA, Chatenoud L

New reagents on the horizon for immune tolerance.

Annual review of medicine

St Clair EW, Turka LA, Saxon A, Matthews JB, Sayegh MH, Eisenbarth GS, Bluestone J

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.

The Journal of experimental medicine

Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA

International trial of the Edmonton protocol for islet transplantation.

The New England journal of medicine

Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR

Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.

Diabetes

Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC

Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI

Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.

The Journal of clinical investigation

Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.

The Journal of experimental medicine

Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs.

The Journal of clinical investigation

Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M

CTLA4Ig: bridging the basic immunology with clinical application.

Immunity

Bluestone JA, St Clair EW, Turka LA

Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential.

Seminars in immunology

Masteller EL, Tang Q, Bluestone JA

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.

Nature immunology

Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.

The Journal of experimental medicine

Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK

Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)

Bour-Jordan H, Thompson HL, Bluestone JA

How do CD4+CD25+ regulatory T cells control autoimmunity?

Current opinion in immunology

Bluestone JA, Tang Q

A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas.

Journal of immunology (Baltimore, Md. : 1950)

Dai YD, Jensen KP, Lehuen A, Masteller EL, Bluestone JA, Wilson DB, Sercarz EE

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.

The Journal of clinical investigation

Bisikirska B, Colgan J, Luban J, Bluestone JA, Herold KC

Achieving antigen-specific tolerance in diabetes: regulating specifically.

International reviews of immunology

Chen W, Bluestone JA, Herold KC

Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)

Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA

A comprehensive review of interventions in the NOD mouse and implications for translation.

Immunity

Shoda LK, Young DL, Ramanujan S, Whiting CC, Atkinson MA, Bluestone JA, Eisenbarth GS, Mathis D, Rossini AA, Campbell SE, Kahn R, Kreuwel HT

B7-independent inhibition of T cells by CTLA-4.

Journal of immunology (Baltimore, Md. : 1950)

Chikuma S, Abbas AK, Bluestone JA

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.

Diabetes

Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA

An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice.

Journal of immunology (Baltimore, Md. : 1950)

Loser K, Scherer A, Krummen MB, Varga G, Higuchi T, Schwarz T, Sharpe AH, Grabbe S, Bluestone JA, Beissert S

Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, Joyce S

Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Kohm AP, Williams JS, Bickford AL, McMahon JS, Chatenoud L, Bach JF, Bluestone JA, Miller SD

Regulatory T-cell therapy: is it ready for the clinic?

Nature reviews. Immunology

Bluestone JA

In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation.

Clinical immunology (Orlando, Fla.)

Earle KE, Tang Q, Zhou X, Liu W, Zhu S, Bonyhadi ML, Bluestone JA

CTLA-4Ig is finally making it: a personal perspective.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Bluestone JA

Differential roles of costimulatory signaling pathways in type 1 diabetes mellitus.

The review of diabetic studies : RDS

Boehm BO, Bluestone JA

The NOD mouse: a model of immune dysregulation.

Annual review of immunology

Anderson MS, Bluestone JA

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.

European journal of immunology

Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA

Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.

The Journal of clinical investigation

Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA

Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes.

Clinical immunology (Orlando, Fla.)

Judkowski V, Rodriguez E, Pinilla C, Masteller E, Bluestone JA, Sarvetnick N, Wilson DB

Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells.

Proceedings of the National Academy of Sciences of the United States of America

Bluestone JA, Tang Q

CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Eagar TN, Turley DM, Padilla J, Karandikar NJ, Tan L, Bluestone JA, Miller SD

In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.

The Journal of experimental medicine

Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA

Notch signaling in lymphocyte development and function.

Current opinion in immunology

Robey EA, Bluestone JA

NKG2D blockade prevents autoimmune diabetes in NOD mice.

Immunity

Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, Lanier LL

Notch 1 signaling regulates peripheral T cell activation.

Immunity

Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA

Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Hering BJ, Kandaswamy R, Harmon JV, Ansite JD, Clemmings SM, Sakai T, Paraskevas S, Eckman PM, Sageshima J, Nakano M, Sawada T, Matsumoto I, Zhang HJ, Sutherland DE, Bluestone JA

Insulin secretion in type 1 diabetes.

Diabetes

Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC

Importance of IL-10 for CTLA-4-mediated inhibition of tumor-eradicating immunity.

Journal of immunology (Baltimore, Md. : 1950)

Jovasevic VM, Gorelik L, Bluestone JA, Mokyr MB

Beta-cell replacement for type I diabetes.

Annual review of medicine

Stock PG, Bluestone JA

Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950)

Masteller EL, Warner MR, Ferlin W, Judkowski V, Wilson D, Glaichenhaus N, Bluestone JA

Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

Nature medicine

Belghith M, Bluestone JA, Barriot S, Mégret J, Bach JF, Chatenoud L

Clinical trials of transplant tolerance: slow but steady progress.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Matthews JB, Ramos E, Bluestone JA

Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis.

The Journal of clinical investigation

Ding W, Beissert S, Deng L, Miranda E, Cassetty C, Seiffert K, Campton KL, Yan Z, Murphy GF, Bluestone JA, Granstein RD

Natural versus adaptive regulatory T cells.

Nature reviews. Immunology

Bluestone JA, Abbas AK

Directed evolution of a single-chain class II MHC product by yeast display.

Protein engineering

Starwalt SE, Masteller EL, Bluestone JA, Kranz DM

CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

The Journal of clinical investigation

Herold KC, Burton JB, Francois F, Poumian-Ruiz E, Glandt M, Bluestone JA

CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.

Nature immunology

Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA

Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

The Journal of experimental medicine

Chikuma S, Imboden JB, Bluestone JA

The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.

Novartis Foundation symposium

Boden E, Tang Q, Bour-Jordan H, Bluestone JA

CTLA-4 and tolerance: the biochemical point of view.

Immunologic research

Chikuma S, Bluestone JA

Impairment of NK cell function by NKG2D modulation in NOD mice.

Immunity

Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA, Lanier LL

When ligand becomes receptor--tolerance via B7 signaling on DCs.

Nature immunology

Finger EB, Bluestone JA

Immunotherapy of insulin-dependent diabetes mellitus.

Current opinion in immunology

Masteller EL, Bluestone JA

Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial.

The Journal of rheumatology

Utset TO, Auger JA, Peace D, Zivin RA, Xu D, Jolliffe L, Alegre ML, Bluestone JA, Clark MR

Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.

Journal of immunology (Baltimore, Md. : 1950)

Hwang KW, Sweatt WB, Brown IE, Blank C, Gajewski TF, Bluestone JA, Alegre ML

The immune tolerance network: a new paradigm for developing tolerance-inducing therapies.

The Journal of allergy and clinical immunology

Rotrosen D, Matthews JB, Bluestone JA

Inability to induce tolerance through direct antigen presentation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Rulifson IC, Szot GL, Palmer E, Bluestone JA

CTLA-4: acting at the synapse.

Molecular interventions

Chikuma S, Bluestone JA

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus.

The New England journal of medicine

Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA

The Src family kinase Fyn mediates signals induced by TCR antagonists.

Journal of immunology (Baltimore, Md. : 1950)

Tang Q, Subudhi SK, Henriksen KJ, Long CG, Vives F, Bluestone JA

The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance.

European journal of immunology

Eagar TN, Karandikar NJ, Bluestone JA, Miller SD

Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.

The Journal of experimental medicine

Salomon B, Rhee L, Bour-Jordan H, Hsin H, Montag A, Soliven B, Arcella J, Girvin AM, Padilla J, Miller SD, Bluestone JA

Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.

Journal of immunology (Baltimore, Md. : 1950)

O'Herrin SM, Slansky JE, Tang Q, Markiewicz MA, Gajewski TF, Pardoll DM, Schneck JP, Bluestone JA

Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy.

The Journal of clinical investigation

Wells AD, Walsh MC, Bluestone JA, Turka LA

Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease.

Journal of immunology (Baltimore, Md. : 1950)

Tesciuba AG, Subudhi S, Rother RP, Faas SJ, Frantz AM, Elliot D, Weinstock J, Matis LA, Bluestone JA, Sperling AI

Suppressor T cells--they're back and critical for regulation of autoimmunity!

Immunological reviews

Chatenoud L, Salomon B, Bluestone JA

ICOS costimulation: It's not just for TH2 cells anymore.

Nature immunology

Sperling AI, Bluestone JA

Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor.

The Journal of experimental medicine

Wu Q, Salomon B, Chen M, Wang Y, Hoffman LM, Bluestone JA, Fu YX

Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells.

Journal of immunology (Baltimore, Md. : 1950)

Donepudi M, Raychaudhuri P, Bluestone JA, Mokyr MB

Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice.

Arteriosclerosis, thrombosis, and vascular biology

Reardon CA, Blachowicz L, White T, Cabana V, Wang Y, Lukens J, Bluestone J, Getz GS

The Immune Tolerance Network: tolerance at the crossroads.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Bluestone JA, Matthews J

Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Szot GL, Zhou P, Rulifson I, Wang J, Guo Z, Kim O, Newel KA, Thistlethwaite JR, Bluestone JA, Alegre ML

Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.

Transplantation proceedings

Zhou P, Szot G, Guo Z, Kim O, He G, Wang J, Grusby M, Newell K, Thistlethwaite J, Bluestone J, Alegre M

Transplantation and the CD28/CTLA4/B7 pathway.

Transplantation proceedings

Alegre M, Fallarino F, Zhou P, Frauwirth K, Thistlethwaite J, Newell K, Gajewski T, Bluestone J

Development and applications of surface-linked single chain antibodies against T-cell antigens.

Journal of immunological methods

Griffin MD, Holman PO, Tang Q, Ashourian N, Korthäuer U, Kranz DM, Bluestone JA

Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML

The immune tolerance network: the "Holy Grail" comes to the clinic.

Journal of the American Society of Nephrology : JASN

Bluestone JA, Matthews JB, Krensky AM

CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis.

Journal of neuroimmunology

Karandikar NJ, Eagar TN, Vanderlugt CL, Bluestone JA, Miller SD

Evidence for functional relevance of CTLA-4 in ultraviolet-radiation-induced tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Schwarz A, Beissert S, Grosse-Heitmeyer K, Gunzer M, Bluestone JA, Grabbe S, Schwarz T

Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells.

Journal of immunology (Baltimore, Md. : 1950)

Sojka DK, Donepudi M, Bluestone JA, Mokyr MB

Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).

Journal of immunology (Baltimore, Md. : 1950)

Griffin MD, Hong DK, Holman PO, Lee KM, Whitters MJ, O'Herrin SM, Fallarino F, Collins M, Segal DM, Gajewski TF, Kranz DM, Bluestone JA

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

Immunity

Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA

Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival.

Transplantation

Szot GL, Zhou P, Sharpe AH, He G, Kim O, Newell KA, Bluestone JA, Thistlethwaite JR

In vitro characterization of five humanized OKT3 effector function variant antibodies.

Cellular immunology

Xu D, Alegre ML, Varga SS, Rothermel AL, Collins AM, Pulito VL, Hanna LS, Dolan KP, Parren PW, Bluestone JA, Jolliffe LK, Zivin RA

Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Vanderlugt CL, Neville KL, Nikcevich KM, Eagar TN, Bluestone JA, Miller SD

A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade.

Journal of immunology (Baltimore, Md. : 1950)

Girvin AM, Dal Canto MC, Rhee L, Salomon B, Sharpe A, Bluestone JA, Miller SD

Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family.

Journal of immunology (Baltimore, Md. : 1950)

Korthäuer U, Nagel W, Davis EM, Le Beau MM, Menon RS, Mitchell EO, Kozak CA, Kolanus W, Bluestone JA

Reduced ultraviolet-induced carcinogenesis in mice with a functional disruption in B7-mediated costimulation.

Journal of immunology (Baltimore, Md. : 1950)

Beissert S, Bluestone JA, Mindt I, Voskort M, Metze D, Mehling A, Luger TA, Schwarz T, Grabbe S

RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.

The Journal of experimental medicine

Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA

CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice.

American journal of respiratory cell and molecular biology

Mathur M, Herrmann K, Qin Y, Gulmen F, Li X, Krimins R, Weinstock J, Elliott D, Bluestone JA, Padrid P

Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection.

Transplantation

Woodle ES, Xu D, Zivin RA, Auger J, Charette J, O'Laughlin R, Peace D, Jollife LK, Haverty T, Bluestone JA, Thistlethwaite JR

Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Newell KA, He G, Guo Z, Kim O, Szot GL, Rulifson I, Zhou P, Hart J, Thistlethwaite JR, Bluestone JA

Induction, maintenance, and reversal of streptozotocin-induced insulin-dependent diabetes mellitus in the juvenile cynomolgus monkey (Macaca fascilularis).

Transplantation

Theriault BR, Thistlethwaite JR, Levisetti MG, Wardrip CL, Szot G, Bruce DS, Rilo H, Li X, Gray GS, Bluestone JA, Padrid PA

Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.

Journal of immunology (Baltimore, Md. : 1950)

Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA

Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4.

Cancer research

Richards J, Auger J, Peace D, Gale D, Michel J, Koons A, Haverty T, Zivin R, Jolliffe L, Bluestone JA

CD2 and CD3 receptor-mediated tolerance: constraints on T cell activation.

Transplantation

Punch JD, Lin J, Bluestone J, Bromberg JS

TCRgammadelta cells and viruses.

Microbes and infection / Institut Pasteur

Sciammas R, Bluestone JA

Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.

Journal of immunology (Baltimore, Md. : 1950)

Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB

The CTLA-4 gene is expressed in placental fibroblasts.

Molecular human reproduction

Kaufman KA, Bowen JA, Tsai AF, Bluestone JA, Hunt JS, Ober C

Molecular basis of T cell inactivation by CTLA-4.

Science (New York, N.Y.)

Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, Straus D, Samelson LE, Thompson CB, Bluestone JA

Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells.

Journal of immunology (Baltimore, Md. : 1950)

La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB

LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production.

Journal of immunology (Baltimore, Md. : 1950)

Salomon B, Bluestone JA

Signalling through the TCR.

Research in immunology

Cantrell D, Bluestone J, Vivier E, Tybulewicz V

Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease.

Journal of neuroimmunology

Karandikar NJ, Vanderlugt CL, Bluestone JA, Miller SD

The functional significance of epitope spreading and its regulation by co-stimulatory molecules.

Immunological reviews

Vanderlugt CL, Begolka WS, Neville KL, Katz-Levy Y, Howard LM, Eagar TN, Bluestone JA, Miller SD

Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer.

Journal of immunology (Baltimore, Md. : 1950)

Ma Y, Thornton S, Duwel LE, Boivin GP, Giannini EH, Leiden JM, Bluestone JA, Hirsch R

Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Karandikar NJ, Vanderlugt CL, Eagar T, Tan L, Bluestone JA, Miller SD

Increased threshold for TCR-mediated signaling controls self reactivity of intraepithelial lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Guehler SR, Finch RJ, Bluestone JA, Barrett TA

Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience.

Transplantation proceedings

Woodle ES, Bluestone JA, Zivin RA, Jolliffe LK, Auger J, Xu D, Thistlethwaite JR

CTLA-4 regulates tolerance induction and T cell differentiation in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Walunas TL, Bluestone JA

CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma.

American journal of respiratory cell and molecular biology

Padrid PA, Mathur M, Li X, Herrmann K, Qin Y, Cattamanchi A, Weinstock J, Elliott D, Sperling AI, Bluestone JA

Importance of the B7-2 molecule for low dose melphalan-induced acquisition of tumor-eradicating immunity by mice bearing a large MOPC-315 tumor.

Journal of immunology (Baltimore, Md. : 1950)

Mokyr MB, Kalinichenko TV, Gorelik L, Bluestone JA

Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.

Journal of immunology (Baltimore, Md. : 1950)

Levisetti MG, Padrid PA, Szot GL, Mittal N, Meehan SM, Wardrip CL, Gray GS, Bruce DS, Thistlethwaite JR, Bluestone JA

Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.

Journal of immunology (Baltimore, Md. : 1950)

Herold KC, Lu J, Rulifson I, Vezys V, Taub D, Grusby MJ, Bluestone JA

Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE.

Journal of neuroimmunology

Vanderlugt CL, Karandikar NJ, Lenschow DJ, Dal Canto MC, Bluestone JA, Miller SD

Transplantation tolerance--putting the pieces together.

Current opinion in immunology

Lechler R, Bluestone JA

T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs.

Current opinion in immunology

Smith JA, Bluestone JA

Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy.

The Journal of experimental medicine

Wick M, Dubey P, Koeppen H, Siegel CT, Fields PE, Chen L, Bluestone JA, Schreiber H

Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic.

Journal of immunology (Baltimore, Md. : 1950)

Sperling AI, Decker DC, DiPaolo RJ, Stern DA, Shum A, Bluestone JA

T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis.

The Journal of experimental medicine

Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA

Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy.

The Journal of experimental medicine

Smith JA, Tso JY, Clark MR, Cole MS, Bluestone JA

Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway.

Journal of immunology (Baltimore, Md. : 1950)

Woodle ES, Smith DM, Bluestone JA, Kirkman WM, Green DR, Skowronski EW

Is CTLA-4 a master switch for peripheral T cell tolerance?

Journal of immunology (Baltimore, Md. : 1950)

Bluestone JA

Class I MHC mediates programmed cell death in a Fas-independent manner.

Transplantation proceedings

Woodle ES, Smith DM, Bluestone JA, Green DR, Skowronski EW

CD28/B7 regulation of autoimmune diabetes.

Immunologic research

Herold KG, Lenschow DJ, Bluestone JA

The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands.

The Journal of experimental medicine

Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN

CD28 costimulation promotes the production of Th2 cytokines.

Journal of immunology (Baltimore, Md. : 1950)

Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA

CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin.

Journal of immunology (Baltimore, Md. : 1950)

Herold KC, Vezys V, Koons A, Lenschow D, Thompson C, Bluestone JA

CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.

Journal of immunology (Baltimore, Md. : 1950)

Sperling AI, Auger JA, Ehst BD, Rulifson IC, Thompson CB, Bluestone JA

The complexities of T-cell co-stimulation: CD28 and beyond.

Immunological reviews

Sperling AI, Bluestone JA

TCR-gamma delta cells in CD3 zeta-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen.

Journal of immunology (Baltimore, Md. : 1950)

Khattri R, Sperling AI, Qian D, Fitch FW, Shores EW, Love PE, Bluestone JA

CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes.

Immunity

Lenschow DJ, Herold KC, Rhee L, Patel B, Koons A, Qin HY, Fuchs E, Singh B, Thompson CB, Bluestone JA

Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts.

The Journal of experimental medicine

Guehler SR, Bluestone JA, Barrett TA

CTLA-4: a negative regulator of autoimmune disease.

The Journal of experimental medicine

Karandikar NJ, Vanderlugt CL, Walunas TL, Miller SD, Bluestone JA

Regulation of CTLA-4 expression during T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Perkins D, Wang Z, Donovan C, He H, Mark D, Guan G, Wang Y, Walunas T, Bluestone J, Listman J, Finn PW

CTLA-4 ligation blocks CD28-dependent T cell activation.

The Journal of experimental medicine

Walunas TL, Bakker CY, Bluestone JA

Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule.

Cancer immunology, immunotherapy : CII

La Motte RN, Rubin MA, Barr E, Leiden JM, Bluestone JA, Mokyr MB

Costimulation and its role in organ transplantation.

Clinical transplantation

Bluestone JA

CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Walunas TL, Sperling AI, Khattri R, Thompson CB, Bluestone JA

IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.

Journal of immunology (Baltimore, Md. : 1950)

Nishimura H, Hiromatsu K, Kobayashi N, Grabstein KH, Paxton R, Sugamura K, Bluestone JA, Yoshikai Y

CD28/B7 system of T cell costimulation.

Annual review of immunology

Lenschow DJ, Walunas TL, Bluestone JA

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE.

Immunity

Miller SD, Vanderlugt CL, Lenschow DJ, Pope JG, Karandikar NJ, Dal Canto MC, Bluestone JA

Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies.

Transplantation

Lenschow DJ, Zeng Y, Hathcock KS, Zuckerman LA, Freeman G, Thistlethwaite JR, Gray GS, Hodes RJ, Bluestone JA

Transplantation.

Current opinion in immunology

Bluestone JA, Lechler RI

Development of TCR gamma delta iIELs.

Seminars in immunology

Barrett TA, Bluestone JA

Functional expression and recognition of nonclassical MHC class I T10b is not peptide-dependent.

Journal of immunology (Baltimore, Md. : 1950)

Kaliyaperumal A, Falchetto R, Cox A, Dick R, Shabanowitz J, Chien YH, Matis L, Hunt DF, Bluestone JA

Ly-6C is a marker of memory CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Walunas TL, Bruce DS, Dustin L, Loh DY, Bluestone JA

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

Journal of immunology (Baltimore, Md. : 1950)

Kearney ER, Walunas TL, Karr RW, Morton PA, Loh DY, Bluestone JA, Jenkins MK

An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity.

Journal of immunology (Baltimore, Md. : 1950)

Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, Bluestone JA

CD43 is a murine T cell costimulatory receptor that functions independently of CD28.

The Journal of experimental medicine

Sperling AI, Green JM, Mosley RL, Smith PL, DiPaolo RJ, Klein JR, Bluestone JA, Thompson CB

Two waves of gamma delta T cells expressing different V delta genes are recruited into schistosome-induced liver granulomas.

Journal of immunology (Baltimore, Md. : 1950)

Sandor M, Sperling AI, Cook GA, Weinstock JV, Lynch RG, Bluestone JA

T cell costimulation through the CD28 receptor.

Proceedings of the Association of American Physicians

Green JM, Noel PJ, Sperling AI, Walunas TL, Lenschow DJ, Stack R, Gray GS, Bluestone JA, Thompson CB

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

The Journal of experimental medicine

Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, Herold KC, Bluestone JA

Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage.

The Journal of biological chemistry

Hu Q, Davidson D, Schwartzberg PL, Macchiarini F, Lenardo MJ, Bluestone JA, Matis LA

Programmed differentiation of murine thymocytes during fetal thymus organ culture.

Journal of immunological methods

DeLuca D, Bluestone JA, Shultz LD, Sharrow SO, Tatsumi Y

TCR gamma delta cells: a specialized T-cell subset in the immune system.

Annual review of cell and developmental biology

Bluestone JA, Khattri R, Sciammas R, Sperling AI

Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors.

Digestive diseases and sciences

Alegre ML, Lenschow DJ, Bluestone JA

Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication.

Journal of immunology (Baltimore, Md. : 1950)

Mokyr MB, Prokhorova A, Rubin M, Bluestone JA

Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies.

Transplantation

Zeng Y, Gage A, Montag A, Rothlein R, Thistlethwaite JR, Bluestone JA

Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.

Journal of immunology (Baltimore, Md. : 1950)

Alegre ML, Peterson LJ, Jeyarajah DR, Weiser M, Bluestone JA, Thistlethwaite JR

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

Journal of immunology (Baltimore, Md. : 1950)

Lenschow DJ, Sperling AI, Cooke MP, Freeman G, Rhee L, Decker DC, Gray G, Nadler LM, Goodnow CC, Bluestone JA

Absence of B7-dependent responses in CD28-deficient mice.

Immunity

Green JM, Noel PJ, Sperling AI, Walunas TL, Gray GS, Bluestone JA, Thompson CB

CTLA-4 can function as a negative regulator of T cell activation.

Immunity

Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA

Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules.

Journal of immunology (Baltimore, Md. : 1950)

Smith DM, Bluestone JA, Jeyarajah DR, Newberg MH, Engelhard VH, Thistlethwaite JR, Woodle ES

The B7 and CD28 receptor families.

Immunology today

June CH, Bluestone JA, Nadler LM, Thompson CB

Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model.

Transplantation

Alegre ML, Sattar HA, Herold KC, Smith J, Tepper MA, Bluestone JA

A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.

Transplantation

Alegre ML, Peterson LJ, Xu D, Sattar HA, Jeyarajah DR, Kowalkowski K, Thistlethwaite JR, Zivin RA, Jolliffe L, Bluestone JA

IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.

Journal of immunology (Baltimore, Md. : 1950)

Stack RM, Lenschow DJ, Gray GS, Bluestone JA, Fitch FW

Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell.

Journal of immunology (Baltimore, Md. : 1950)

Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG, Fitch FW, Bluestone JA

Prolongation of human pancreatic islet xenografts by pretreatment of islets with anti-human ICAM-1 monoclonal antibody.

Transplantation proceedings

Zeng Y, Torres MA, Thistlethwaite JR, Montag A, Bluestone JA

Cooperation between staphylococcal enterotoxin B and low dose melphalan in the cure of mice bearing a large MOPC-315 tumor and extensive metastases.

Journal of immunology (Baltimore, Md. : 1950)

Rubin M, Bluestone JA, Newell KA, Prokhorova A, Mokyr MB

The nature of major histocompatibility complex recognition by gamma delta T cells.

Cell

Schild H, Mavaddat N, Litzenberger C, Ehrich EW, Davis MM, Bluestone JA, Matis L, Draper RK, Chien YH

TCR gamma delta cells: mysterious cells of the immune system.

Immunologic research

Sciammas R, Tatsumi Y, Sperling AI, Arunan K, Bluestone JA

The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America

Qian D, Sperling AI, Lancki DW, Tatsumi Y, Barrett TA, Bluestone JA, Fitch FW

T-cell receptor gamma delta diversity and specificity of intestinal intraepithelial lymphocytes: analysis of IEL-derived hybridomas.

Cellular immunology

Sydora BC, Mixter PF, Houlden B, Hershberg R, Levy R, Comay M, Bluestone J, Kronenberg M

Role of gamma delta T cells in murine collagen-induced arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Peterman GM, Spencer C, Sperling AI, Bluestone JA

Expression and functional significance of an additional ligand for CTLA-4.

Proceedings of the National Academy of Sciences of the United States of America

Lenschow DJ, Su GH, Zuckerman LA, Nabavi N, Jellis CL, Gray GS, Miller J, Bluestone JA

CD28-mediated costimulation is necessary for the activation of T cell receptor-gamma delta+ T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Sperling AI, Linsley PS, Barrett TA, Bluestone JA

Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan.

Journal of immunology (Baltimore, Md. : 1950)

Mokyr MB, Rubin M, Newell KA, Prokhorova A, Bluestone JA

Peptide-induced changes in class I heavy chains alter allorecognition.

Journal of immunology (Baltimore, Md. : 1950)

Bluestone JA, Kaliyaperumal A, Jameson S, Miller S, Dick R

T cell co-stimulation and in vivo tolerance.

Current opinion in immunology

Lenschow DJ, Bluestone JA

Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes.

European journal of immunology

Dent AL, Matis LA, Bluestone JA, Hedrick SM

Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation.

Journal of immunology (Baltimore, Md. : 1950)

Tatsumi Y, Pena JC, Matis L, Deluca D, Bluestone JA

Alloantibodies can discriminate class I major histocompatibility complex molecules associated with various endogenous peptides.

Proceedings of the National Academy of Sciences of the United States of America

Sherman LA, Chattopadhyay S, Biggs JA, Dick RF, Bluestone JA

Tolerance of T cell receptor gamma/delta cells in the intestine.

The Journal of experimental medicine

Barrett TA, Tatsumi Y, Bluestone JA

Non-classical MHC molecules: the first line of defence?

Current biology : CB

Sperling AI, Bluestone JA

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.

The Journal of experimental medicine

Wells FB, Tatsumi Y, Bluestone JA, Hedrick SM, Allison JP, Matis LA

Immunosuppressive effects of anti-CD3 MAb and soluble co-stimulatory molecules.

Transplantation proceedings

Bluestone JA, Bruce D, Peterson L, Thistlethwaite JR, Josephson M, Zeng Y, Linsley PS, Lenschow DJ

Long-term functional xenograft tolerance after intrathymic islet transplantation (Lewis rat-->B6 mouse).

Transplantation proceedings

Zeng Y, Bluestone JA, Ildstad ST, Torres MA, Montag AG, Thistlethwaite RJ

Nonmitogenic anti-CD3F(ab')2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier.

Journal of immunology (Baltimore, Md. : 1950)

Blazar BR, Taylor PA, Snover DC, Bluestone JA, Vallera DA

Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition.

The Journal of experimental medicine

Bluestone JA, Jameson S, Miller S, Dick R

Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection.

Journal of immunology (Baltimore, Md. : 1950)

Sperling AI, Cron RQ, Decker DC, Stern DA, Bluestone JA

Differential function of intestinal intraepithelial lymphocyte subsets.

Journal of immunology (Baltimore, Md. : 1950)

Barrett TA, Gajewski TF, Danielpour D, Chang EB, Beagley KW, Bluestone JA

Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg.

Science (New York, N.Y.)

Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, Linsley PS, Bluestone JA

Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.

Journal of immunology (Baltimore, Md. : 1950)

Alegre ML, Collins AM, Pulito VL, Brosius RA, Olson WC, Zivin RA, Knowles R, Thistlethwaite JR, Jolliffe LK, Bluestone JA

Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression.

Journal of immunology (Baltimore, Md. : 1950)

Woodle ES, Thistlethwaite JR, Jolliffe LK, Zivin RA, Collins A, Adair JR, Bodmer M, Athwal D, Alegre ML, Bluestone JA

In vitro and in vivo activation of murine gamma/delta T cells induces the expression of IgA, IgM, and IgG Fc receptors.

Journal of immunology (Baltimore, Md. : 1950)

Sandor M, Houlden B, Bluestone J, Hedrick SM, Weinstock J, Lynch RG

The T cell receptor in autoimmune diseases.

The Journal of rheumatology. Supplement

Bluestone JA, Spencer C, Hirsch R

Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody.

Diabetes

Herold KC, Bluestone JA, Montag AG, Parihar A, Wiegner A, Gress RE, Hirsch R

A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I.

Journal of immunology (Baltimore, Md. : 1950)

Johnson RM, Lancki DW, Sperling AI, Dick RF, Spear PG, Fitch FW, Bluestone JA

A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice.

The Journal of experimental medicine

Hiromatsu K, Yoshikai Y, Matsuzaki G, Ohga S, Muramori K, Matsumoto K, Bluestone JA, Nomoto K

Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue.

The Journal of experimental medicine

Barrett TA, Delvy ML, Kennedy DM, Lefrancois L, Matis LA, Dent AL, Hedrick SM, Bluestone JA

Activation of T cells in vivo using anti-CD3 and staphylococcal enterotoxins.

International journal of cancer. Supplement = Journal international du cancer. Supplement

Bluestone JA, Bruce DS, Newell KA

Immunopotentiation of anti-viral and anti-tumor immune responses using anti-T cell receptor antibodies and mitogens.

Annals of the New York Academy of Sciences

Newell KA, Ellenhorn JD, Hirsch R, Bluestone JA

Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.

Journal of immunology (Baltimore, Md. : 1950)

Taguchi T, Aicher WK, Fujihashi K, Yamamoto M, McGhee JR, Bluestone JA, Kiyono H

Inter-mouse strain differences in the in vivo anti-CD3 induced cytokine release.

Clinical and experimental immunology

Ferran C, Dy M, Sheehan K, Merite S, Schreiber R, Landais P, Grau G, Bluestone J, Bach JF, Chatenoud L

Requirement for positive selection of gamma delta receptor-bearing T cells.

Science (New York, N.Y.)

Wells FB, Gahm SJ, Hedrick SM, Bluestone JA, Dent A, Matis LA

Anti-CD3 monoclonal antibody therapy. An approach toward optimization by in vitro analysis of new anti-CD3 antibodies.

Transplantation

Woodle ES, Thistlethwaite JR, Jolliffe LK, Fucello AJ, Stuart FP, Bluestone JA

Repertoire development and ligand specificity of murine TCR gamma delta cells.

Immunological reviews

Bluestone JA, Cron RQ, Barrett TA, Houlden B, Sperling AI, Dent A, Hedrick S, Rellahan B, Matis LA

Specificity of gamma delta receptor bearing T cells.

Seminars in immunology

Matis LA, Bluestone JA

T-cell activation and lymphokine production induced by antihuman CD3 monoclonal antibodies.

Transplantation proceedings

Woodle ES, Thistlethwaite JR, Jolliffe LK, Ghobrial I, Fuccello AJ, Stuart FP, Bluestone JA

In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor.

Proceedings of the National Academy of Sciences of the United States of America

Newell KA, Ellenhorn JD, Bruce DS, Bluestone JA

Junctional sequences influence the specificity of gamma/delta T cell receptors.

The Journal of experimental medicine

Rellahan BL, Bluestone JA, Houlden BA, Cotterman MM, Matis LA

Signal transduction through class I MHC by a monoclonal antibody that detects multiple murine and human class I molecules.

Journal of immunology (Baltimore, Md. : 1950)

Houlden BA, Widacki SM, Bluestone JA

Selection of V delta+ T cell receptors of intestinal intraepithelial lymphocytes is dependent on class II histocompatibility antigen expression.

Current topics in microbiology and immunology

Lefrancois L, LeCorre R, Mayo J, Bluestone JA, Goodman T

Control of self-reactivity in the intestine.

Immunologic research

Barrett TA, Hedrick SM, Dent AL, Delvy ML, Kennedy DM, Matis LA, Bluestone JA

Ligand specificity and repertoire development of murine TCR gamma delta cells.

Current topics in microbiology and immunology

Bluestone JA, Cron RQ, Rellahan B, Matis LA

Freshly isolated Thy-1+ dendritic epidermal cells express T cell receptor gamma delta-CD3.

Journal of dermatological science

Shimada S, Caughman SW, Bluestone JA, Cron RQ, Owen FL, Smith JA, Katz SI

T lymphocyte activation following OKT3 treatment.

Current surgery

Ellenhorn JD, Woodle ES, Thistlethwaite JR, Bluestone JA

Activation of human T cells in vivo following treatment of transplant recipients with OKT3.

Transplantation

Ellenhorn JD, Woodle ES, Ghobreal I, Thistlethwaite JR, Bluestone JA

Treatment with monoclonal anti-CD3 antibody protects against lethal Sendai virus infection by induction of natural killer cells.

Journal of immunology (Baltimore, Md. : 1950)

Kast WM, Bluestone JA, Heemskerk MH, Spaargaren J, Voordouw AC, Ellenhorn JD, Melief CJ

Reduction of morbidity and cytokine release in anti-CD3 MoAb-treated mice by corticosteroids.

Transplantation

Ferran C, Dy M, Merite S, Sheehan K, Schreiber R, Leboulenger F, Landais P, Bluestone J, Bach JF, Chatenoud L

Are TCR alpha beta cells and TCR gamma delta cells that different?

Research in immunology

Bluestone JA, Matis LA

Structural basis of Kbm8 alloreactivity. Amino acid substitutions on the beta-pleated floor of the antigen recognition site.

Journal of immunology (Baltimore, Md. : 1950)

Hunt HD, Pullen JK, Dick RF, Bluestone JA, Pease LR

T cell receptor delta-gene expression and diversity in the mouse spleen.

Journal of immunology (Baltimore, Md. : 1950)

Ezquerra A, Cron RQ, McConnell TJ, Valas RB, Bluestone JA, Coligan JE

Neurotoxicity after treatment with muromonab-CD3.

The New England journal of medicine

Richards JM, Vogelzang NJ, Bluestone JA

In vivo T lymphocyte activation induced in mice following the injection of anti-CD3 monoclonal antibody.

Transplantation proceedings

Ferran C, Bluestone J, Bach JF, Chatenoud L

Expression of a T cell receptor gamma-chain (V gamma 1.1J gamma 4C gamma 4) transgene in mice influences T cell receptor ontogeny and thymic architecture during development.

Journal of immunology (Baltimore, Md. : 1950)

Ferrick DA, Chan A, Rahemtulla A, Widacki SM, Xia M, Broughton H, Gajewski DA, Ballhausen W, Allison JP, Bluestone JA

Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice.

Journal of immunology (Baltimore, Md. : 1950)

Ellenhorn JD, Schreiber H, Bluestone JA

Cytokine-related syndrome following injection of anti-CD3 monoclonal antibody: further evidence for transient in vivo T cell activation.

European journal of immunology

Ferran C, Sheehan K, Dy M, Schreiber R, Merite S, Landais P, Noel LH, Grau G, Bluestone J, Bach JF

Self-reactive gamma delta T cells are eliminated in the thymus.

Nature

Dent AL, Matis LA, Hooshmand F, Widacki SM, Bluestone JA, Hedrick SM

Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.

Cell

Grusby MJ, Nabavi N, Wong H, Dick RF, Bluestone JA, Schotz MC, Glimcher LH

Identification of distinct T cell receptor (TCR)-gamma delta heterodimers using an anti-TCR-gamma variable region serum.

Journal of immunology (Baltimore, Md. : 1950)

Cron RQ, Ezquerra A, Coligan JE, Houlden BA, Bluestone JA, Maloy WL

Structure and specificity of a class II MHC alloreactive gamma delta T cell receptor heterodimer.

Science (New York, N.Y.)

Matis LA, Fry AM, Cron RQ, Cotterman MM, Dick RF, Bluestone JA

Anti-CD3 antibody for autoimmune disease, a cautionary note.

Lancet (London, England)

Hirsch R, Gress RE, Bluestone JA

Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.

Journal of immunology (Baltimore, Md. : 1950)

Cron RQ, Gajewski TF, Sharrow SO, Fitch FW, Matis LA, Bluestone JA

Suppression of the humoral response to anti-CD3 monoclonal antibody.

Transplantation

Hirsch R, Chatenoud L, Gress RE, Sachs DH, Bach JF, Bluestone JA

TCR gamma delta cells--minor redundant T cell subset or specialized immune system component?

Journal of immunology (Baltimore, Md. : 1950)

Bluestone JA, Matis LA

Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells.

Journal of immunology (Baltimore, Md. : 1950)

Hirsch R, Gress RE, Pluznik DH, Eckhaus M, Bluestone JA

Dose-dependent activation of murine T cells following in vivo administration of anti-murine CD3.

Transplantation proceedings

Ellenhorn JD, Hirsch R, Hartley JP, Bluestone JA

Suppression of the humoral response to anti-CD3 mAB by pretreatment with anti-CD4 mAB.

Transplantation proceedings

Hirsch R, Chatenoud L, Gress RE, Bach JF, Sachs DH, Bluestone JA

T helper 2 (Th2) but not Th1 clones co-stimulate resting T cells in the presence of anti-CD3 monoclonal antibody.

International immunology

Evavold BD, Yokoyama A, Hirsch R, Bluestone JA, Quintans J

A TCR gamma delta cell recognizing a novel TL-encoded gene product.

Cold Spring Harbor symposia on quantitative biology

Houlden BA, Matis LA, Cron RQ, Widacki SM, Brown GD, Pampeno C, Meruelo D, Bluestone JA

Systematic development of distinct T cell receptor-gamma delta T cell subsets during fetal ontogeny.

Journal of immunology (Baltimore, Md. : 1950)

Houlden BA, Cron RQ, Coligan JE, Bluestone JA

Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.

The Journal of experimental medicine

Bluestone JA, Cron RQ, Cotterman M, Houlden BA, Matis LA

In vivo administration of anti-CD3 prevents malignant progressor tumor growth.

Science (New York, N.Y.)

Ellenhorn JD, Hirsch R, Schreiber H, Bluestone JA

Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor gamma delta structures.

Journal of immunology (Baltimore, Md. : 1950)

Cron RQ, Koning F, Maloy WL, Pardoll D, Coligan JE, Bluestone JA

CD3-associated heterodimeric polypeptides on suppressor hybridomas define biologically active inhibitory cells.

Proceedings of the National Academy of Sciences of the United States of America

Weiner DB, Liu J, Hanna N, Bluestone JA, Coligan JE, Williams WV, Greene MI

Cytotoxic T lymphocyte recognition of novel allodeterminants expressed on in vitro selected H-2Kb mutants.

Journal of immunology (Baltimore, Md. : 1950)

Lewis J, Foo M, Geier SS, Kumar PA, Nathenson SG, Bluestone JA

Selective expression of the Ly-6C.2 epitope on Lyt-2+ T cells that can develop in the absence of thymic influence.

Journal of immunology (Baltimore, Md. : 1950)

Leo O, Foo M, Forman J, Shivakumar S, Rabinowitz R, Bluestone JA

Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor.

Cell

Ajitkumar P, Geier SS, Kesari KV, Borriello F, Nakagawa M, Bluestone JA, Saper MA, Wiley DC, Nathenson SG

Thymus-dependent and thymus-independent developmental pathways for peripheral T cell receptor-gamma delta-bearing lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Pardoll DM, Fowlkes BJ, Lew AM, Maloy WL, Weston MA, Bluestone JA, Schwartz RH, Coligan JE, Kruisbeek AM

Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses.

Journal of immunology (Baltimore, Md. : 1950)

Hirsch R, Eckhaus M, Auchincloss H, Sachs DH, Bluestone JA

Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.

Journal of immunology (Baltimore, Md. : 1950)

Tentori L, Pardoll DM, Zuñiga JC, Hu-Li J, Paul WE, Bluestone JA, Kruisbeek AM

Class II antigen-specific murine cytolytic T lymphocytes (CTL). II. Genuine class II specificity of Lyt-2+ CTL clones.

Journal of immunology (Baltimore, Md. : 1950)

Shinohara N, Hozumi N, Watanabe M, Bluestone JA, Johnson-Leva R, Sachs DH

Inhibition of transformed T cell growth in vitro by monoclonal antibodies directed against distinct activating molecules.

Journal of immunology (Baltimore, Md. : 1950)

Mercep M, Bluestone JA, Noguchi PD, Ashwell JD

Role of Ti/CD3, Thy-1, and Ly-6 in cytolytic T-cell activation analyzed with Ti loss variants.

Annals of the New York Academy of Sciences

Langlet C, Guimezanes A, Kaldy P, Boyer C, Buferne M, Poenie M, Tsien R, Leo O, Bluestone J, Leserman L

Role of accessory molecules in signal transduction of cytolytic T lymphocyte by anti-T cell receptor and anti-Ly-6.2C monoclonal antibodies.

Journal of immunology (Baltimore, Md. : 1950)

Leo O, Foo M, Henkart PA, Perez P, Shinohara N, Segal DM, Bluestone JA

Structure and expression of class I MHC genes in the miniature swine.

Veterinary immunology and immunopathology

Singer DS, Ehrlich R, Satz L, Frels W, Bluestone J, Hodes R, Rudikoff S

T cell antigen receptor phosphorylation induced by an anti-receptor antibody.

Journal of immunology (Baltimore, Md. : 1950)

Samelson LE, O'Shea JJ, Luong H, Ross P, Urdahl KB, Klausner RD, Bluestone J

T cell receptor tyrosine phosphorylation. Variable coupling for different activating ligands.

The Journal of biological chemistry

Klausner RD, O'Shea JJ, Luong H, Ross P, Bluestone JA, Samelson LE

Thy-1+ dendritic epidermal cells express T3 antigen and the T-cell receptor gamma chain.

Proceedings of the National Academy of Sciences of the United States of America

Stingl G, Koning F, Yamada H, Yokoyama WM, Tschachler E, Bluestone JA, Steiner G, Samelson LE, Lew AM, Coligan JE

Cytotoxic T lymphocyte recognition of a xenogeneic major histocompatibility complex antigen expressed in transgenic mice.

European journal of immunology

Bluestone JA, Pescovitz MD, Frels WI, Singer DS, Hodes RJ

Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer.

The Journal of experimental medicine

Yokoyama WM, Koning F, Stingl G, Bluestone JA, Coligan JE, Shevach EM

Differential expression of two distinct T-cell receptors during thymocyte development.

Nature

Pardoll DM, Fowlkes BJ, Bluestone JA, Kruisbeek A, Maloy WL, Coligan JE, Schwartz RH

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

Proceedings of the National Academy of Sciences of the United States of America

Leo O, Foo M, Sachs DH, Samelson LE, Bluestone JA

Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Takayama H, Trenn G, Humphrey W, Bluestone JA, Henkart PA, Sitkovsky MV

Analysis of T-cell receptor gamma chain expression in the thymus.

Advances in experimental medicine and biology

Pardoll DM, Lew AM, Maloy WL, Fowlkes BJ, Kruisbeek A, Bluestone JA, Schwartz RH, Coligan JE

Identification of monoclonal antibodies specific for the T cell receptor complex by Fc receptor-mediated CTL lysis.

Journal of immunology (Baltimore, Md. : 1950)

Leo O, Sachs DH, Samelson LE, Foo M, Quinones R, Gress R, Bluestone JA

Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes.

Science (New York, N.Y.)

Lew AM, Pardoll DM, Maloy WL, Fowlkes BJ, Kruisbeek A, Cheng SF, Germain RN, Bluestone JA, Schwartz RH, Coligan JE

Expression and function of asialo GM1 in alloreactive cytotoxic T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Ting CC, Bluestone JA, Hargrove ME, Loh NN

Somatic cell variants express altered H-2Kb allodeterminants recognized by cytolytic T cell clones.

Journal of immunology (Baltimore, Md. : 1950)

Bluestone JA, Langlet C, Geier SS, Nathenson SG, Foo M, Schmitt-Verhulst AM

Cloned cytotoxic T lymphocytes that recognize an I-A region product in the context of a class I antigen.

The Journal of experimental medicine

Shinohara N, Bluestone JA, Sachs DH

Idiotypic manipulation of the immune response to transplantation antigens.

Immunological reviews

Bluestone JA, Leo O, Epstein SL, Sachs DH

Serologic and T cell recognition of truncated transplantation antigens encoded by in vitro deleted class I major histocompatibility genes.

Journal of immunology (Baltimore, Md. : 1950)

McCluskey J, Bluestone JA, Coligan JE, Maloy WL, Margulies DH

Evidence for a regulatory idiotypic network in the in vivo response to H-2 antigens.

The Journal of experimental medicine

Rabinowitz R, Bluestone JA, Sachs DH

Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody.

Nature

Perez P, Hoffman RW, Shaw S, Bluestone JA, Segal DM

Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance.

The Journal of experimental medicine

Ildstad ST, Wren SM, Bluestone JA, Barbieri SA, Sachs DH

Allospecific cytolytic T lymphocytes recognize conformational determinants on hybrid mouse transplantation antigens.

The Journal of experimental medicine

Bluestone JA, Foo M, Allen H, Segal D, Flavell RA

Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.

Science (New York, N.Y.)

Frels WI, Bluestone JA, Hodes RJ, Capecchi MR, Singer DS

Molecular localization of allogeneic and self determinants recognized by bulk and clonal populations of cytotoxic T cells.

Journal of immunology (Baltimore, Md. : 1950)

Levy RB, Ozato K, Richardson JC, Bluestone JA

The role of cytoplasmic granules in cytotoxicity by large granular lymphocytes and cytotoxic T lymphocytes.

Advances in experimental medicine and biology

Henkart P, Henkart M, Millard P, Frederikse P, Bluestone J, Blumenthal R, Yue C, Reynolds C

The regulation of the immune system.

Immunology today

Hodes RJ, Germain RN, Bluestone JA

CTL recognize different determinants from those defined serologically on Ld somatic cell mutants.

Journal of immunology (Baltimore, Md. : 1950)

Bluestone JA, Potter TA, Chatterjee-Hasrouni S, Rajan TV

Serological analysis of H-2 mutations using monoclonal antibodies.

Journal of immunogenetics

Bluestone JA, McKenzie IF, Melvold RW, Ozato K, Sandrin MS, Sharrow SO, Sachs DH

Cell-surface molecules involved in T-cell functions.

Immunology today

Bluestone JA, Hodes RJ

Anti-idiotypes against anti-H-2 antibodies VI. Detection of shared idiotypes among monoclonal anti-H-2 antibodies.

European journal of immunology

Bluestone JA, Auchincloss H, Sachs DH, Fibi M, Hämmerling GJ

Idiotypes of anti-major histocompatibility complex antibodies.

Annals of the New York Academy of Sciences

Sachs DH, Bluestone JA, Epstein SL, Rabinowitz R

The presence of a common idiotype in anti-H-2 immune sera as detected by anti-idiotype to a monoclonal anti-H-2 antibody.

European journal of immunology

Ozato K, Epstein SL, Bluestone JA, Sharrow SO, Hansen T, Sachs DH

Anti-idiotypes against anti-H-2 monoclonal antibodies: structural analysis of the molecules induced by in vivo anti-idiotype treatment.

Proceedings of the National Academy of Sciences of the United States of America

Bluestone JA, Krutzsch HC, Auchincloss H, Cazenave PA, Kindt TJ, Sachs DH

Anti-idiotypes to monoclonal anti-H-2 antibodies. III. Syngeneic anti-idiotypes on antibodies induced by in vivo administration of xenogeneic anti-idiotypes.

Journal of immunology (Baltimore, Md. : 1950)

Bluestone JA, Auchincloss H, Cazenave PA, Ozato K, Sachs DH

Idiotypes of anti-Ia antibodies. II. Effects of in vivo treatment with xenogeneic anti-idiotype.

Journal of immunology (Baltimore, Md. : 1950)

Epstein SL, Masakowski VR, Sharrow SO, Bluestone JA, Ozato K, Sachs DH

Idiotypes of anti-Ia antibodies. I. Expression of the 14-4-4S idiotype in humoral immune responses.

The Journal of experimental medicine

Epstein SL, Ozato K, Bluestone JA, Sachs DH

Antiidiotypes to monoclonal anti-H-2 and anti-Ia hybridoma antibodies.

Transplantation proceedings

Sachs DH, Bluestone JA, Epstein SL, Ozato K