Daniel Goodman, PhD

Postdoctoral Scholar
(co-advised by Alex Marson and Kole Roybal)
Microbiology and Immunology

Immune receptors are surprisingly modular and can be mutated and composed to rewire cellular inputs and outputs, as showcased by the success of cell-based genetic therapies like Chimeric Antigen Receptor T-cell (CAR-T) therapy. My work involves high-throughput pooled screening of thousands of different synthetic receptors. A better understanding of the relationship between receptor sequence, signaling outcome, and cellular phenotype will lead to next-generation cell-based genetic therapies which manipulate the immune system to combat a variety of diseases.

Publications: 

A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions.

Molecular cell

Cheung R, Insigne KD, Yao D, Burghard CP, Wang J, Hsiao YE, Jones EM, Goodman DB, Xiao X, Kosuri S

Causes and effects of N-terminal codon bias in bacterial genes.

Science (New York, N.Y.)

Goodman DB, Church GM, Kosuri S

Composability of regulatory sequences controlling transcription and translation in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America

Kosuri S, Goodman DB, Cambray G, Mutalik VK, Gao Y, Arkin AP, Endy D, Church GM